IM176OUT05 is a high solubility biguanide. IM176OUT05 activates stem cell metabolism, promotes hair regrowth and increases stemness induction and maintenance during the pluripotent stem cell generation process. IM176OUT0 inhibits mitochondrial electron transport chain (ETC) activity with an IC50 of 3.2 μM[1].
IM176OUT05 (0.1-10 μM；24 小时) 抑制线粒体功能，降低氧消耗率 (OCR) 以抑制线粒体电子传递链 (ETC) 活性，IC50 为 3.2 μM[1]。
IM176OUT05 (10 μM；6 天) 改善小鼠和人诱导多能干细胞 (iPSCs) 的干细胞多能性的获取和维持[1]。
IM176OUT05 (10 和 100 nM) 促进糖酵解代谢的转变，诱导糖酵解相关基因和 ETC 复合酶的表达[1]。
IM176OUT05 (200 μL, 1%；用于脱毛区域，每日一次) 通过刺激毛囊周期和增加毛囊数量，促进小鼠毛发再生[1]。
| Animal Model: | 7-week-old C57BL/6 mice[1] |
| Dosage: | 200 μL, 1% |
| Administration: | Apply to the depilated area; 200 μL, 1%, once daily |
| Result: | Strongly promoted the hair regrowth, especially in female mice. |
[1]. Son MJ, et al. A novel and safe small molecule enhances hair follicle regeneration by facilitating metabolic reprogramming. Exp Mol Med. 2018 Dec 6;50(12):1-15.