GlpBio

IHVR-19029

目录号: GC39492纯度: >98.00%
IHVR-19029 是一种有效的内质网 α-葡萄糖苷酶 Ⅰ 和 Ⅱ (α-glucosidases I/II) 抑制剂，对 ER α-葡萄糖苷酶 Ⅰ 的 IC50 为0.48 μM。IHVR-19029 能有效阻断几种出血热病毒的复制，如登革病毒、埃博拉病毒和裂谷热病毒。
IHVR-19029
Cas No.: 1447464-73-4
规格价格库存数量操作
5mg¥4,050.00现货
1
10mg¥7,020.00现货
1
50mg¥17,100.00现货
1
100mg¥25,200.00现货
1
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文献被引

本产品暂无引用记录;以下为 GlpBio 产品在 Nature / Cell / Science 等顶刊的客户引用样例
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    Cell
    187(9):2288-2304 (2024)
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    Cell
    183(7):1867-1883 (2020)
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    33, 904–922 (2023)
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    31, 1291–1307 (2021)

产品描述 Description

IHVR-19029 is a potent endoplasmic reticulum (ER) α-glucosidases I and II inhibitor, with an IC50 of 0.48 μM for ER a-glucosidase I. IHVR-19029 efficiently blocks the replication of several hemorrhagic fever viruses, such as Dengue virus (DENV), Ebola virus (EBOV) and Rift Valley fever virus[1][2][3].

[1]. Bray M, et al. Meeting report: 31st International Conference on Antiviral Research. Antiviral Res. 2018 Oct;158:88-102. [2]. Jin hong Chang, et al. Small molecule inhibitors of ER α-glucosidases are active against multiple hemorrhagic fever viruses. Antiviral Research. Volume 98, Issue 3, June 2013, Pages 432-440. [3]. Ester Prodrugs of IHVR-19029 with Enhanced Oral Exposure and Prevention of Gastrointestinal Glucosidase Interaction.ACS Med Chem Lett. 2017 Jan 17;8(2):157-162. [4]. Ma J, et al. Enhancing the antiviral potency of ER α-glucosidase inhibitor IHVR-19029 against hemorrhagic fever viruses in vitro and in vivo. Antiviral Res. 2018 Feb;150:112-122.

产品文档 Product Documents

Purity:>98.00%

化学性质Chemical Properties

CAS 号
1447464-73-4
SMILES
O=C(NC(C)(C)C)N(C1CCCCC1)CCCCCCN2[C@H](CO)[C@@H](O)[C@H](O)[C@@H](O)C2
分子式
C23H45N3O5
分子量
443.62 g/mol
溶解性
DMSO: 250 mg/mL (563.55 mM)
保存条件
Store at -20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol