Hydrogenated soybean phospholipids, commonly used as a liposomal carrier for drug delivery, can enhance the stability of liposomes composed of stratum corneum lipids (SC lipids) under neutral pH conditions[1-3]. Hydrogenated soybean phospholipids can enhance the encapsulation of curcumin in liposomes, improve the stability of curcumin-loaded liposomes, slow the release of curcumin during simulated digestion, and promote tighter lipid packing in liposomal membranes[4].
References:
[1] Zhao W, Zeng M, Li K, et al. Solid lipid nanoparticle as an effective drug delivery system of a novel curcumin derivative: formulation, release in vitro and pharmacokinetics in vivo. Pharm Biol. 2022;60(1):2300-2307.
[2] Wu H, Yu M, Miao Y, et al. Cholesterol-tuned liposomal membrane rigidity directs tumor penetration and anti-tumor effect. Acta Pharm Sin B. 2019;9(4):858-870.
[3] Strati F, Mukhina T, Neubert RHH, et al. Cerosomes as skin repairing agent: Mode of action studies with a model stratum corneum layer at liquid/air and liquid/solid interfaces. BBA Adv. 2021;2:100039.
[4] Tai K, Rappolt M, Mao L, Gao Y, Yuan F. Stability and release performance of curcumin-loaded liposomes with varying content of hydrogenated phospholipids. Food Chem. 2020;326:126973.
Hydrogenated soybean phospholipids常被用作药物递送的脂质体载体，并且能够在中性pH条件下增强由角质层脂质（SC脂质）组成的脂质体的稳定性[1-3]。Hydrogenated soybean phospholipids还可以提高脂质体包封姜黄素的能力，增强载姜黄素脂质体的稳定性，减缓姜黄素在模拟消化过程中的释放，并促进脂质体膜中脂质的紧密排列[4]。