GRL-0496 is an inhibitor of severe acute respiratory syndrome coronavirus (SARS-CoV) and SARS-CoV-2 main protease (Mpro), also known as 3C-like protease (3CLpro; IC50s = 0.03 and 0.038 ?M, respectively).1,2 It reduces viral infectivity in SARS-CoV-infected Vero cells (EC50 = 6.9 ?M).1
1.Ghosh, A.K., Gong, G., Grum-Tokars, V., et al.Design, synthesis and antiviral efficacy of a series of potent chloropyridyl ester-derived SARS-CoV 3CLpro inhibitorsBioorg. Med. Chem. Lett.18(20)5684-5688(2008) 2.Cao, W., Cho, C.-C.D., Geng, Z.Z., et al.Evaluation of SARS-CoV-2 main protease inhibitors using a novel cell-based assayACS Cent. Sci.8(2)192-204(2022)