Glycohyocholic acid (GHCA) is a glycine-conjugated form of the primary bile acid hyocholic acid .[1] GHCA is upregulated 6.6-fold in the serum of patients with cirrhosis induced by hepatitis C virus (HCV) compared to healthy controls.[2] Plasma levels of GHCA increase in patients who are no longer diabetic following gastric bypass surgery.[3]
Reference:
[1]. Guo, L., Milburn, M.V., Ryals, J.A., et al. Plasma metabolomic profiles enhance precision medicine for volunteers of normal health. Proc. Nat. Acad. Sci. USA 112(35), E4901-E4910 (2015).
[2]. Fitian, A.I., Nelson, D.R., Liu, C., et al. Integrated metabolomic profiling of hepatocellular carcinoma in hepatitis C cirrhosis through GC/MS and UPLC/MS-MS. Liver Int. 34(9), 1428-1444 (2014).
[3]. Yu, H., Ni, Y., Bao, Y., et al. Chenodeoxycholic acid as a potential prognostic marker for roux-en-Y gastric bypass in chinese obese patients. J. Clin. Endocrinol. Metab. 100(11), 4222-4230 (2015).