Triamcinolone acetonide-d7 is intended for use as an internal standard for the quantification of triamcinolone acetonide by GC- or LC-MS. Triamcinolone acetonide is a synthetic corticosteroid.1 It decreases cytokine levels, the firing rate of sensory neurons, and mechanical hypersensitivity in a rat spinal nerve ligation model when used at a dose of 1.5 mg/kg prior to and following surgery for three days. Triamcinolone acetonide also decreases outflow facility in a mouse model of steroid-induced glaucoma when 20 μl of a 40 mg/ml suspension is administered subconjunctivally.2 Formulations containing triamcinolone acetonide are used in the treatment of diabetic macular edema.
References
1. Li, H., Xie, W., Strong, J.A., et al. Systemic antiinflammatory corticosteroid reduces mechanical pain behavior, sympathetic sprouting, and elevation of proinflammatory cytokines in a rat model of neuropathic pain. Anesthesiology 107(3), 469-477 (2007).
2. Kumar, S., Shah, S., Deutsch, E.R., et al. Triamcinolone acetonide decreases outflow facility in C57BL/6 mouse eyes. Invest. Ophthalmol. Vis. Sci. 54(2), 1280-1287 (2013).