Histone H3K79Me1 (69-89) amide is a peptide fragment of histone H3 that corresponds to amino acid residues 70-90 of the human histone H3.1 and H3.2 sequences. Methylation of lysine 79 on histone H3 is associated with active chromatin and the silencing of telomere-associated genes by silent information regulator (Sir) proteins.1 The conversion of H3K79Me1 to H3K79Me2/3 is associated with increased expression of mixed lineage leukemia (MLL) target genes, including Hoxa9.2
References
1. Bhaumik, S.R., Smith, E., and Shilatifard, A. Covalent modifications of histones during development and disease pathogenesis. Nat. Struct. Mol. Biol. 14(11), 1008-1016 (2007).
2. Deshpande, A.J., Deshpande, A., Sinha, A.U., et al. AF10 regulates progressive H3K79 methylation and HOX gene expression in diverse AML subtypes. Cancer Cell 26(6), 896-908 (2014).