3-Mercaptopicolinic acid is an inhibitor of gluconeogenesis. In perfused rat livers, gluconeogenesis was inhibited when lactate, pyruvate, or alanine served as substrate, but not with fructose, suggesting phosphoenolpyruvate carboxykinase as the site of inhibition.1,2,3
1.DiTullio, N.W., Berkoff, C.E., Blank, B., et al.3-mercaptopicolinic acid, an inhibitor of gluconeogenesisBiochem. J.138(3)387-394(1974) 2.Robinson, B.H., and Oei, J.3-Mercaptopicolinic acid, a preferential inhibitor of the cytosolic phosphoenolpyruvate carboxykinaseFEBS Lett.58(1)12-15(1975) 3.Hidalgo, J., Latorre, P., Carrodeguas, J.A., et al.Inhibition of pig phosphoenolpyruvate carboxykinase isoenzymes by 3-mercaptopicolinic acid and novel inhibitorsPLoS One11(7)e0159002(2016)