Dehydrotumulosic acid is a triterpene that has been found in P. cocos and has anticancer and anti-inflammatory activities.1,2 It enhances the cytotoxicity of vincristine against multidrug-resistant KBv200 cells when used at concentrations of 12.5 or 25 ?g/ml.1 Dehydrotumulosic acid (50 mg/kg) reduces serotonin-induced hind paw edema, as well as ear edema induced by phorbol 12-myristate 13-acetate , in mice.2
1.Shan, H., Qinglin, Z., Fengjun, X., et al.Reversal of multidrug resistance of KBV200 cells by triterpenoids isolated from Poria cocosPlanta Med.78(5)428-433(2012) 2.Giner, E.M., Má?ez, S., Recio, M.C., et al.In vivo studies on the anti-inflammatory activity of pachymic and dehydrotumulosic acidsPlanta Med.66(3)221-227(2000)