Tacalcitol monohydrate

Vitamin D aids in the absorption of calcium and has central roles in bone formation and maintenance, hypertension, cancer, and immunity.^1,2 In addition, the active form of vitamin D, 1,25-dihydroxy vitamin D₃, decreases the proliferation and increases differentiation of keratinocytes.³ 1,24-dihydroxy Vitamin D₃ is an analog of 1,25-dihydroxy vitamin D₃ which, when used in a 4 μg/g ointment, safely and effectively suppresses psoriasis.⁴ It also is effective at increasing the time interval between phototherapy cycles when ultraviolet light is used for psoriasis.⁵ 1,24-dihydroxy Vitamin D₃ inhibits the growth of both normal and psoriatic human keratinocytes (IC₅₀ ~ 10 nM) via the vitamin D receptor.⁶ It also suppresses the production of RANTES and IL-8 by human dermal fibroblasts and reduces cutaneous lymphocyte-associated antigen on CD4⁺ T cells, impairing migration and skin infiltration.^7,8

1.Holick, M.F.Vitamin D deficiencyN. Engl. J. Med.357(3)266-281(2007) 2.Peterlik, M., Boonen, S., Cross, H.S., et al.Vitamin D and calcium insufficiency-related chronic diseases: An emerging world-wide public health problemInt. J. Environ. Res. Public Health6(10)2585-2607(2009) 3.Bikle, D.D.1,25(OH)2D3-regulated human keratinocyte proliferation and differentiation: Basic studies and their clinical applicationJ. Nutr.1251709S-1714S(1995) 4.Leone, G., and Pacifico, A.Profile of clinical efficacy and safety of topical tacalcitolActa Biomed.76(1)13-19(2005) 5.Prignano, F., Buggiani, G., and Lotti, T.Clinical evaluation of topical tacalcitol efficacy in extending the remission period between nb-UVB phototherapy cycles in psoriatic patientsActa Biomed.8051-56(2009) 6.Matsumoto, K., Hashimoto, K., Kiyoki, M., et al.Effect of 1,24R-dihydroxyvitamin D3 on the growth of human keratinocytesJ. Dermatol.17(2)97-103(1990) 7.Fukuoka, M., Ogino, Y., Sato, H., et al.Regulation of RANTES and IL-8 production in normal human dermal fibroblasts by active vitamin D3 (tacalcitol)Br. J. Pharmacol.124(7)1433-1438(1998) 8.Yamanaka, K.I., Kakeda, M., Kitagawa, H., et al.1,24-Dihydroxyvitamin D3 (tacalcitol) prevents skin T-cell infiltrationBr. J. Dermatol.162(6)1206-1215(2010)