α-Linolenic acid methyl ester is a natural methylated form of α-linolenic acid .1,2 Unlike α-linolenic acid, linolenic acid methyl ester is a poor agonist of GPR120, does not inhibit voltage-dependent calcium channels in β-cells, and only weakly inhibits melanogenesis in mouse B16 melanoma cells.3,4,5
1.Go, J.V., Rezanka, T., Srebnik, M., et al.Variability of fatty acid components of murine and freshwater gastropod speices from the littoral zone of the Red Sea, Mediterranean Sea, and Sea of GalileeBiochem. Syst. Ecol.30819-835(2002) 2.Mohadjerani, M., Hosseinzadeh, R., and Hosseini, M.Chemical composition and antibacterial properties of essential oil and fatty acids of different parts of Ligularia persica BoissAvicenna J. Phytomed.6(3)357-365(2016) 3.Sun, Q., Hirasawa, A., Hara, T., et al.Structure-activity relationships of GPR120 agonists based on a docking simulationMol. Pharm.78804-810(2010) 4.Feng, D.-D., Zhao, Y.-F., Luo, Z.-Q., et al.Linoleic acid induces Ca2+-induced inactivation of voltage-dependent Ca2+ currents in rat pancreatic β-cellsJ. Endocrinol.196(2)377-384(2008) 5.Huh, S., Kim, Y.-S., Jung, E., et al.Melanogenesis inhibitory effect of fatty acid alkyl esters isolated from Oxalis triangularisBiol. Pharm. Bull.33(7)1242-1245(2010)