Leucokinin VIII is an diuretic octapeptide isolated form head extracts of the cockroach.
Leucokinin VIII is an octapeptide, increases the rates of transepithelial NaC1, KC1 and water secretion, increases the Cl conductance of the epithelial shunt via a receptor located at the basolateral side of the epithelium[1]. Leucokinin VIII also activates Ca2+-dependent signal pathway in principal cells of Aedes aegyptiMalpighian tubules[2].
[1]. Pannabecker TL, et al. Regulation of epithelial shunt conductance by the peptide leucokinin. J Membr Biol. 1993 Feb;132(1):63-76. [2]. Yu MJ, et al. Leucokinin activates Ca(2+)-dependent signal pathway in principal cells of Aedes aegypti Malpighian tubules. Am J Physiol Renal Physiol. 2002 Sep;283(3):F499-508.