Laminin (925-933) is a peptide fragment corresponding to the laminin β1 chain.1 It binds to the laminin receptor when used at a concentration of 1 mg/ml. Laminin (925-933) stimulates the attachment of HT-1080 and CHO cells to culture plates when used at concentrations of 100 and 300 ?g/ml. It induces chemotaxis of, as well as inhibits chemotaxis induced by full-length laminin, but not fibronectin, in B16/F10 murine melanoma cells. Laminin (925-933) conjugated to an agarose hydrogel backbone enhances neurite outgrowth in isolated chick embryo dorsal root ganglia and PC12 cells.2
1.Graf, J., Iwamoto, Y., Sasaki, M., et al.Identification of an amino acid sequence in laminin mediating cell attachment, chemotaxis, and receptor bindingCell48(6)989-996(1987) 2.Bellamkonda, R., Ranieri, J.P., and Aebischer, P.Laminin oligopeptide derivatized agarose gels allow three-dimensional neurite extension in vitroJ. Neurosci. Res.41(4)501-509(1995)