Isomeranzin is a coumarin that has been found in C. grandis and has antioxidant and anti-inflammatory activities.1,2 It inhibits superoxide anion generation in, and elastase release from, isolated human neutrophils stimulated with cytochalasin B and fMLP (IC50s = 3.89 and 4.33 ?M, respectively).1 Isomeranzin (30 ?M) inhibits LPS-induced nitric oxide (NO) release in RAW 264.7 macrophages.2 It improves survival in a mouse model of LPS-induced septic shock and decreases disease severity in a mouse model of colitis induced by dextran sulfate when administered at a dose of 30 mg/kg.
1.Kuo, P.-C., Liao, Y.-R., Hung, H.-Y., et al.Anti-inflammatory and neuroprotective constituents from the peels of Citrus grandisMolecules22(6)967(2017) 2.Xu, G., Feng, L., Song, P., et al.Isomeranzin suppresses inflammation by inhibiting M1 macrophage polarization through the NF-κB and ERK pathwayInt. Immunopharmacol.38175-185(2016)