GlpBio

Ibiglustat L-Malic acid

目录号: GC36288纯度: >98.00%同义词: Venglustat (L-Malic acid); SAR402671 (L-Malic acid); GZ402671 (L-Malic acid)
Ibiglustat succinate (Venglustat succinate) is a glucosylceramide (GlcCer) synthase inhibitor that blocks the formation of glucosylceramide.
Ibiglustat L-Malic acid
Cas No.: 1629063-78-0
规格价格库存数量操作
1mg¥448.00现货
1
5mg¥1,260.00现货
1
10mg¥2,070.00现货
1
25mg¥3,285.00现货
1
50mg¥4,860.00现货
1
10mM (in 1mL DMSO)¥1,452.00现货
1
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产品描述 Description

Ibiglustat succinate (Venglustat succinate) is a glucosylceramide (GlcCer) synthase inhibitor that blocks the formation of glucosylceramide.

Ibiglustat succinate can prevent additional globotriaosylceramide(GL-3) accumulation and could serve to ameliorate the abundant levels of this sphingolipid in fabry disease cardiomyocytes.[2]

Venglustat administration signifcantly reduces the accumulation of glycosphingolipids and pathological α-synuclein aggregates in the central nervous system and ameliorated the associated memory defcit. [3]

[1] Zappa F, et al. Curr Opin Cell Biol. 2018 Feb;50:102-116. [2] Itier JM, et al. J Inherit Metab Dis. 2014 Nov;37(6):1013-22. [3] Viel C, et al. Sci Rep. 2021 Oct 22;11(1):20945.

产品文档 Product Documents

Purity:>98.00%

化学性质Chemical Properties

CAS 号
1629063-78-0
同义词
Venglustat (L-Malic acid); SAR402671 (L-Malic acid); GZ402671 (L-Malic acid)
SMILES
O=C(O[C@@H]1CN2CCC1CC2)NC(C)(C3=CSC(C4=CC=C(F)C=C4)=N3)C.OC(C[C@H](O)C(O)=O)=O
分子式
C24H30FN3O7S
分子量
523.57 g/mol
溶解性
DMSO: ≥ 100 mg/mL (191.00 mM)
保存条件
Store at -20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol