D-Desthiobiotin is a protein cross-linking agent and a precursor in the synthesis of biotin .1 It has been used in the preparation of agarose matrices for affinity-based isolation of streptavidin-fluorophore conjugates.
1.Hirsch, J.D., Eslamizar, L., Filanoski, B.J., et al.Easily reversible desthiobiotin binding to streptavidin, avidin, and other biotin-binding proteins: Uses for protein labeling, detection, and isolationAnal. Biochem.308(2)343-357(2002)