Continentalic acid is a diterpenic acid that has been found in A. continentalis and has diverse biological activities.1,2,3,4 It is active against methicillin-susceptible S. aureus (MSSA) and clinical isolates of methicillin-resistant S. aureus (MRSA; MICs = 8 and 8-16 ?g/ml, respectively).1 Continentalic acid (200 ?M) induces apoptosis in U-2932, OCI-LY1, and Ramos (RA 1) B cell lymphoma cells.2 In vivo, continentalic acid (50 mg/kg) decreases blood glucose levels, total body weight, and serum triglyceride, total cholesterol, and LDL levels, as well as increases serum HDL levels in a rat model of diabetes induced by alloxan .3 It also improves renal function and decreases renal malondialdehyde (MDA) and peroxidase levels, nitric oxide (NO) production, and neutrophil infiltration in a mouse model of E. coli- and LPS-induced renal injury.4
1.Jeong, S.-I., Han, W.-S., Yun, Y.-H., et al.Continentalic acid from Aralia continentalis shows activity against methicillin-resistant Staphylococcus aureusPhytother. Res.20(6)511-514(2006) 2.Jeon, B.-E., Kwon, C.-S., Lee, J.-E., et al.Anticancer activity of continentalic acid in B-cell lymphomaMolecules26(22)6845(2021) 3.Liaquat, I., Khan, A.-U., and Khan, S.Pharmacological evaluation of continentalic acid for antidiabetic potentialBiomed. Pharmacother.138111411(2021) 4.Khan, A.M., Khan, A.U., Ali, H., et al.Continentalic acid exhibited nephroprotective activity against the LPS and E. coli-induced kidney injury through inhibition of the oxidative stress and inflammationInt. Immunopharmacol.80106209(2020)