Chebulic acid is a phenol that has been found in T. chebular and has diverse biological activities.1,2,3 It reduces production of reactive oxygen species (ROS) in human umbilical vein endothelial cells (HUVECs) induced by glyceraldehyde-related advanced glycation end products (glycer-AGEs) when used at a concentration of 100 ?g/ml.1 Chebulic acid reduces glycer-AGE-induced adhesion of HUVECs to THP-1 monocytes. It induces Nrf2 nuclear translocation and glutathione (GSH) synthesis and inhibits glycer-AGE-induced collagen accumulation, a marker of fibrosis, in LX-2 hepatic stellate cells.2 In vivo, chebulic acid (25 and 50 mg/kg) increases serum insulin levels and reduces blood urea nitrogen levels, proteinuria, albuminuria, and serum glucose levels in a diabetic rat model of ischemia-reperfusion-induced nephropathy.3
1.Lee, H.-S., Koo, Y.-C., Suh, H.J., et al.Preventive effects of chebulic acid isolated from Terminalia chebula on advanced glycation endproduct-induced endothelial cell dysfunctionJ. Ethnopharmacol.131(3)567-574(2010) 2.Koo, Y.-C., Pyo, M.C., Nam, M.-H., et al.Chebulic acid prevents hepatic fibrosis induced by advanced glycation end-products in LX-2 cell by modulating Nrf2 translocation via ERK pathwayToxicol. In Vitro348-15(2016) 3.Silawat, N., and Gupta, V.B.Chebulic acid attenuates ischemia reperfusion induced biochemical alteration in diabetic ratsPharm. Biol.51(1)23-29(2013)