Hederoside D2 is a triterpenoid saponin originally isolated from C. robustum rhizome and roots and has diverse biological activities.1,2 It induces potassium release and hemolysis in mouse erythrocytes in a pH-dependent manner when used at a concentration of 10 μg/ml.2 Hederoside D2 is cytotoxic to N1E-115 neuroblastoma cells at low pH. It induces proliferation of human embryonic fibroblasts in acidic medium, an effect that can be blocked by the calcium channel blockers verapamil , diltiazem, and nitrendipine .
1.Murakami, T., Nagasawa, M., Urayama, S., et al.New triterpenoid saponins in the rhizome and roots of Caulophyllum robustumYakugaku Zasshi88(3)321-324(1968) 2.Likhatskaya, G.N., Aminin, D.L., Agafonova, I.G., et al.The pH-dependent channels formed by cauloside CAdvances in Experimental Medicine and Biology404239-249(1996)