Astringin is a phenolic stilbene glucoside that has been found in V. vinifera and has antioxidant and antineoplastic activities.1,2 It scavenges 2,2-diphenyl-1-picrylhydrazyl radicals (IC50 = 30.2 μM) in a cell-free assay and inhibits cupric ion-induced lipid peroxidation of human LDL (IC50 = 3 μM).1 Astringin (10 ?g/ml) inhibits development of preneoplastic lesions induced by 7,12-dimethylbenz(a)anthracene (DMBA) in mouse mammary gland organ cultures by 68.8%.2
1.Tegeo, P.W., Fauconneau, B., Deffieux, G., et al.Isolation, identification, and antioxidant activity of three stilbene glucosides newly extracted from Vitis vinifera cell culturesJ. Nat. Prod.61(5)655-657(1998) 2.Waffo-Téguo, P., Hawthorne, M.E., Cuendet, M., et al.Potential cancer-chemopreventive activities of wine stilbenoids and flavans extracted from grape (Vitis vinifera) cell culturesNutr. Cancer40(2)173-179(2001)