7-Xylosyltaxol is a taxane and derivative of paclitaxel that has been found in T. chinensis and has microtubule disruptor and anticancer activities.1,2,3 It induces the disassembly of pig brain and Physarum microtubules in cell-free assays (IC50s = 0.2 and 0.4 ?M, respectively).2 7-Xylosyltaxol inhibits proliferation of A549, MCF-7, A2780, HCT-8, and SW480 cancer cells with IC50 values of 0.39, 0.16, 0.85, 5.9, and 5.6 ?M, respectively.3
1.Yu, S.-S., Sun, Q.-W., Zhang, X.-P., et al.Content and distribution of active components in cultivated and wild Taxus chinensis var. mairei plantsYing Yong Sheng Tai Xue Bao23(10)2641-2647(2012) 2.Lataste, H., Senilh, V., Wright, M., et al.Relationships between the structures of taxol and baccatine III derivatives and their in vitro action on the disassembly of mammalian brain and Physarum amoebal microtubulesProc. Natl. Acad. Sci. USA81(13)4090-4094(1984) 3.Sun, Z.-H., Chen, Y., Guo, Y.-Q., et al.Isolation and cytotoxicity evaluation of taxanes from the barks of Taxus wallichiana var. maireiBioorg. Med. Chem. Lett.25(6)1240-1243(2015)