Gastrin I (human) is an endogenous peptide present in the stomach, which acts on cholecystokinin 2 receptor to promote gastric acid secretion[1]. Gastrin I (human) plays important role in stimulating the initiation and development of many gastrointestinal diseases[2]. Gastrin I (human) induces parathyroid hormone-like hormone expression in gastric parietal cells[3].
Gastrin I (human) (25μM; 15, 30, 45min) stimulates trypsin and chymotrypsin secretion from yellowtail pyloric caeca/pancreatic cell[4]. Gastrin I (human) (10 or 100nmol/l; 48h) enhances transcription of genes involved in islet cell function and identity in donors with higher HbA1c (>42 mmol/mol)[5].
Gastrin I (human) (20μg/kg; i.p. ; 24h and 40min) improved renal function and alleviates pathological damage after renal ischemic/reperfusion injury of mice model[6]. Gastrin I (human) (15nmol/kg; i.v. ; 20min) and Cholecystokinin-8S (CCK-8S (15nmol/kg; i.v. ; 20min)) significantly increased the release of NO breakdown products into the rat gastric lumen[7].
References:
[1] NOBLE F, WANK S A, CRAWLEY J N, et al. International Union of Pharmacology. XXI. Structure, distribution, and functions of cholecystokinin receptors [J]. Pharmacological reviews, 1999, 51(4): 745-81.
[2] YANG K, JIN H, GAO X, et al. Elucidating the molecular determinants in the process of gastrin C-terminal pentapeptide amide end activating cholecystokinin 2 receptor by Gaussian accelerated molecular dynamics simulations [J]. Front Pharmacol, 2022, 13(1054575.
[3] AL MENHALI A, KEELEY T M, DEMITRACK E S, et al. Gastrin induces parathyroid hormone-like hormone expression in gastric parietal cells [J]. Am J Physiol Gastrointest Liver Physiol, 2017, 312(6): G649-G57.
[4] KOFUJI P Y, MURASHITA K, HOSOKAWA H, et al. Effects of exogenous cholecystokinin and gastrin on the secretion of trypsin and chymotrypsin from yellowtail (Seriola quinqueradiata) isolated pyloric caeca [J]. Comp Biochem Physiol A Mol Integr Physiol, 2007, 146(1): 124-30.
[5] IRWIN N, LENZ A, LENZ G, et al. Islets from human donors with higher but not lower hemoglobin A1c levels respond to gastrin treatment in vitro [J]. Plos One, 2019, 14(8):
[6] LIU C, CHEN K, WANG H, et al. Gastrin Attenuates Renal Ischemia/Reperfusion Injury by a PI3K/Akt/Bad-Mediated Anti-apoptosis Signaling [J]. Front Pharmacol, 2020, 11(540479.
[7] BLANDIZZI C, LAZZERI G, COLUCCI R, et al. CCK1 and CCK2 receptors regulate gastric pepsinogen secretion [J]. Eur J Pharmacol, 1999, 373(1): 71-84.
Gastrin I (human) 是存在于胃内的内源性肽，作用于缩胆囊素受体2，促进胃酸分泌[1]。Gastrin I (human) 在刺激许多胃肠道疾病的发生和进展中起着重要作用[2]。Gastrin I (human) 诱导胃壁细胞中甲状旁腺激素样激素表达[3]。
Gastrin I (human)（25μM; 15, 30, 45min）刺激黄尾鱼幽门盲肠/胰腺细胞胰蛋白酶和凝乳胰蛋白酶的分泌[4]。Gastrin I (human)（10 or 100nmol; 48h）在HbA1c（>42 mmol/mol）较高浓度的胰岛供体中增强与胰岛细胞功能和身份相关的基因转录[5]。
使用Gastrin I (human)（20μg/kg; i.p. ; 24h and 40min）处理小鼠肾缺血/再灌注模型，Gastrin I (human)可减轻小鼠的肾病理损伤[6]。使用Gastrin I (human)（15nmol/kg; i.v. ; 20min）和CCK-8S（Cholecystokinin-8S，胆囊收缩素8S (15nmol/kg; i.v. ; 20min)）处理大鼠，Gastrin I (human) 显著增加了大鼠胃腔内NO代谢产物的释放[7]。