n-Octylpolyoxyethylene is a nonionic surfactant that can dissolve membrane proteins and is used for protein solubilization, purification, and crystallization. Its critical micelle concentration (CMC) value is 6.6mM[1, 2]. The CMC value is defined as the minimum concentration at which surfactant molecules in a solvent associate to form micelles[3]. n-Octylpolyoxyethylene can be used as an antibacterial agent, possibly inhibiting bacterial growth by disrupting the bacterial cell membrane or interfering with the synthesis of proteins required for bacterial growth[4].
References:
[1] Hollingsworth K. The synthesis of a maltose responsive switch[D]. University of Leeds, 2015.
[2] Žuna K, Jovanović O, Khailova L S, et al. Mitochondrial uncoupling proteins (UCP1-UCP3) and adenine nucleotide translocase (ANT1) enhance the protonophoric action of 2, 4-dinitrophenol in mitochondria and planar bilayer membranes[J]. Biomolecules, 2021, 11(8): 1178.
[3] Hait S K, Moulik S P. Determination of critical micelle concentration (CMC) of nonionic surfactants by donor‐acceptor interaction with lodine and correlation of CMC with hydrophile‐lipophile balance and other parameters of the surfactants[J]. Journal of Surfactants and Detergents, 2001, 4(3): 303-309.
[4] Wang Q, Ko K S, Kapus A, et al. A spirochete surface protein uncouples store-operated calcium channels in fibroblasts: a novel cytotoxic mechanism[J]. Journal of Biological Chemistry, 2001, 276(25): 23056-23064.
n-Octylpolyoxyethylene是一种非离子表面活性剂， 可溶解膜蛋白，用于蛋白质溶解、纯化和结晶，其临界胶束浓度（CMC）值为6.6mM[1, 2]。CMC值的定义是表面活性剂分子在溶剂中缔合形成胶束的最低浓度[3]。n-Octylpolyoxyethylene可用作抗菌剂，可能通过破坏细菌的细胞膜或干扰细菌生长所需蛋白质的合成来抑制细菌的生长[4]。