L-threo-Phenylserine is a β-hydroxy-α-amino acid with two chiral centers. L-threo-Phenylserine can be efficiently synthesized via a transaldolase reaction catalyzed by L-threonine transaldolase, using L-threonine and benzaldehyde as substrates. L-threo-Phenylserine can serve as a substrate for detecting the activity of related enzymes[1-2].
References:
[1] Misono H, Maeda H, Tuda K, et al. Characterization of an inducible phenylserine aldolase from Pseudomonas putida 24-1. Appl Environ Microbiol. 2005 Aug;71(8):4602-9.
[2] Waditee-Sirisattha R, Sittipol D, Tanaka Y, et al. Overexpression of serine hydroxymethyltransferase from halotolerant cyanobacterium in Escherichia coli results in increased accumulation of choline precursors and enhanced salinity tolerance. FEMS Microbiol Lett. 2012 Aug;333(1):46-53.
L-threo-Phenylserine是一种具有两个手性中心的β-羟基-α-氨基酸。L-threo-Phenylserine可通过L-苏氨酸转醛酶催化L-苏氨酸和苯甲醛的转醛醇反应高效合成。L-threo-Phenylserine可作为检测相关酶活的底物[1-2]。