Copeptin is a peptide composed of 39-amino acids that is produced primarily in paraventricular neurons and the supraoptic nucleus of the hypothalamus[1].
Copeptin may aid in the folding of vasopressin during transport. Vasopressin has a direct antidiuretic effect on the kidneys and also causes constriction of peripheral blood vessels. Copeptin can be used as a vasopressin surrogate in clinical test[2-4].
In vivo£¬In In the analysis of systemic anaphylaxis, the body temperature of the model group (Compound 48/80) was significantly lower than that of the control group. Compound 48/80 induced increased serum concentrations of HIS, TNF-¦Á and IL-8[8]. Compound 48/80-induced MC degranulation produced anticonvulsive effects against PTZ-induced epileptic seizures by extending the onset time of both myoclonic-jerk and generalized tonic¨Cclonic seizure, and by shortening the duration of generalized tonic¨Cclonic seizure[9].
References:
[1]. Baranowska B, Kochanowski J. Copeptin - a new diagnostic and prognostic biomarker in neurological and cardiovascular diseases. Neuro Endocrinol Lett. 2019 Dec;40(5):207-214. PMID: 32112544.
[2]. Balanescu S, Kopp P, Gaskill MB, Morgenthaler NG, Schindler C, Rutishauser J. Correlation of plasma copeptin and vasopressin concentrations in hypo-, iso-, and hyperosmolar States. J Clin Endocrinol Metab. 2011 Apr;96(4):1046-52. doi: 10.1210/jc.2010-2499. Epub 2011 Feb 2. PMID: 21289257.
[3]. Morgenthaler NG, Struck J, Alonso C, Bergmann A. Assay for the measurement of copeptin, a stable peptide derived from the precursor of vasopressin. Clin Chem. 2006 Jan;52(1):112-9. doi: 10.1373/clinchem.2005.060038. Epub 2005 Nov 3. PMID: 16269513.
[4]. Christ-Crain M. Vasopressin and Copeptin in health and disease. Rev Endocr Metab Disord. 2019 Sep;20(3):283-294. doi: 10.1007/s11154-019-09509-9. PMID: 31656992.
和肽素是一种由 39 个氨基酸组成的肽，主要产生于下丘脑的室旁神经元和视上核[1]。
和肽素可能有助于加压素在运输过程中的折叠。加压素对肾脏有直接的抗利尿作用，也会引起外周血管收缩。和肽素可作为血管加压素的替代物进行临床试验[2-4]。
In vivo:在全身过敏反应分析中，模型组（Compound 48/80）的体温明显低于对照组。化合物 48/80 诱导 HIS、TNF-α 和 IL-8[8] 血清浓度升高。化合物 48/80 诱导的 MC 脱颗粒通过延长肌阵挛发作和全身性强直性发作的发作时间，以及缩短全身性强直性发作的持续时间，对 PTZ 诱导的癫痫发作产生抗惊厥作用[9 ].