Autoinducing Peptide I is a quorum-sensing autoinducing peptide secreted by Staphylococcus aureus[1]. Autoinducing Peptide I acts as a specific agonist of the AgrC histidine kinase receptor and potently activates the agr system[2]. Upon binding and activating AgrC, Autoinducing Peptide I triggers the expression of virulence genes including RNAIII, and regulates the production of bacterial exotoxins, hemolysins, and other pathogenic factors[3]. Autoinducing Peptide I is widely used in the study of bacterial quorum sensing and virulence regulation mechanisms[4][5]. Autoinducing Peptide I is also used in studies of anti-infective mechanisms and novel antibacterial adjuvants, providing structural templates and target validation for the development of new antimicrobial therapies[6][7].
References:
[1] Lyon GJ, Wright JS, Muir TW, Novick RP. Key determinants of receptor activation in the agr autoinducing peptides of Staphylococcus aureus. Biochemistry. 2002;41(31):10095-10104.
[2] Wang B, Zhao A, Novick RP, Muir TW. Activation and inhibition of the receptor histidine kinase AgrC occurs through opposite helical transduction motions. Mol Cell. 2014;53(6):929-940.
[3] Gordon CP, Olson SD, Lister JL, Kavanaugh JS, Horswill AR. Truncated Autoinducing Peptides as Antagonists of Staphylococcus lugdunensis Quorum Sensing. J Med Chem. 2016;59(19):8879-8888.
[4] Arvidson S, Tegmark K. Regulation of virulence determinants in Staphylococcus aureus. Int J Med Microbiol. 2001;291(2):159-170.
[5] Tal-Gan Y, Stacy DM, Foegen MK, Koenig DW, Blackwell HE. Highly potent inhibitors of quorum sensing in Staphylococcus aureus revealed through a systematic synthetic study of the group-III autoinducing peptide. J Am Chem Soc. 2013;135(21):7869-7882.
[6] Daly SM, Joyner JA, Triplett KD, et al. VLP-based vaccine induces immune control of Staphylococcus aureus virulence regulation. Sci Rep. 2017;7(1):637.
[7] Tal-Gan Y, Ivancic M, Cornilescu G, Cornilescu CC, Blackwell HE. Structural characterization of native autoinducing peptides and abiotic analogues reveals key features essential for activation and inhibition of an AgrC quorum sensing receptor in Staphylococcus aureus. J Am Chem Soc. 2013;135(49):18436-18444.
Autoinducing Peptide I是由金黄色葡萄球菌分泌的一种群体感应自诱导肽[1]。Autoinducing Peptide I是AgrC组氨酸激酶受体的特异性激动剂，可高效激活agr系统[2]。Autoinducing Peptide I通过结合并激活AgrC，启动RNAⅢ等毒力基因的表达，从而调控细菌外毒素、溶血素等多种致病因子的产生[3]。Autoinducing Peptide I常用于细菌群体感应与毒力调控机制研究[4][5]。Autoinducing Peptide I也用于抗感染机制及新型抗菌佐剂的研究，为开发新型抗菌策略提供结构模板和靶点验证[6][7]。