1,2-Dimyristoyl-rac-glycero-3-phosphocholine

1,2-Dimyristoyl-rac-glycero-3-phosphocholine, a zwitterionic phospholipid, was chosen as a simple but suitable membrane model of the human cell membrane for mimicking the neutral charge of the surface membrane of eukaryotic plasma membranes^[1]. The effect of antibiotics such as Rifabutin on human cell membrane models was assessed using multilamellar vesicles (MLVs) composed of 1,2-Dimyristoyl-rac-glycero-3-phosphocholine^[1-2]. 1,2-Dimyristoyl-rac-glycero-3-phosphocholine can serve as a model lipid membrane to study the effects of DMSO and drugs on eukaryotic cell membranes^[3-5]. 1,2-Dimyristoyl-rac-glycero-3-phosphocholine can also be used to prepare polydiacetylene (PDA)^[6]. 1,2-Dimyristoyl-rac-glycero-3-phosphocholine experiences an increase in headgroup area, enhanced membrane disorder, and increased fluidity due to DMSO, but the bilayer does not disintegrate^[4].

References:
[1] Pinheiro M, Nunes C, Caio JM, et al. The influence of rifabutin on human and bacterial membrane models: implications for its mechanism of action. J Phys Chem B. 2013;117(20):6187-6193.
[2] Pinheiro M, Nunes C, Caio JM, Moiteiro C, Brezesinski G, Reis S. Interactions of N'-acetyl-rifabutin and N'-butanoyl-rifabutin with lipid bilayers: a synchrotron X-ray study. Int J Pharm. 2013;453(2):560-568.
[3] Kundu S, Malik S, Ghosh M, et al. A Comparative Study on DMSO-Induced Modulation of the Structural and Dynamical Properties of Model Bilayer Membranes. Langmuir. 2021;37(6):2065-2078.
[4] Sahu S, Garg A, Saini R, Debnath A. Interface Water Assists in Dimethyl Sulfoxide Crossing and Poration in Model Bilayer. Langmuir. 2024;40(11):5764-5775.
[5] Pinheiro M, Amenitsch H, Reis S. Antituberculosis Drug Interactions with Membranes: A Biophysical Approach Applied to Bedaquiline. Membranes (Basel). 2019;9(11):141.
[6] Jung YK, Park HG. Colorimetric detection of clinical DNA samples using an intercalator-conjugated polydiacetylene sensor. Biosens Bioelectron. 2015;72:127-132.

1,2-Dimyristoyl-rac-glycero-3-phosphocholine是一种两性离子磷脂，被选作简单且合适的人类细胞膜模型，用于模拟真核细胞质膜表面的电中性^[1]。通过使用由1,2-Dimyristoyl-rac-glycero-3-phosphocholine组成的多层脂质体（MLVs），评估了如利福布汀等抗生素对人类细胞膜模型的影响^[1-2]。1,2-Dimyristoyl-rac-glycero-3-phosphocholine可以作为模型脂质膜，用于研究DMSO和药物对真核细胞膜的影响^[3-5]。此外，1,2-Dimyristoyl-rac-glycero-3-phosphocholine还可用于制备聚二乙炔（PDA）^[6]。由于DMSO的作用，1,2-Dimyristoyl-rac-glycero-3-phosphocholine的头基面积增大，膜的无序性增强，流动性增加，但双层膜并未解体^[4]。