α-Synuclein (61-95) (human) is a core hydrophobic region of human α-synuclein (α-Synuclein), containing the amino acid sequence from 61 to 95 (NAC region, Non-Amyloid-β Component), which was originally isolated from the insoluble core of Alzheimer's disease (AD) amyloid plaques[1, 2]. α-Synuclein (61-95) (human) can induce neuronal cell death and can be used to study neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease (PD)[3, 4].
References:
[1] Emadi S, Liu R, Yuan B, et al. Inhibiting aggregation of α-synuclein with human single chain antibody fragments[J]. Biochemistry, 2004, 43(10): 2871-2878.
[2] Bisaglia M, Trolio A, Bellanda M, et al. Structure and topology of the non‐amyloid‐β component fragment of human α‐synuclein bound to micelles: Implications for the aggregation process[J]. Protein science, 2006, 15(6): 1408-1416.
[3] Forloni G, Bertani I, Calella A M, et al. α‐Synuclein and Parkinson's disease: Selective neurodegenerative effect of α‐synuclein fragment on dopaminergic neurons in vitro and in vivo[J]. Annals of neurology, 2000, 47(5): 632-640.
[4] Tabner B J, Turnbull S, El-Agnaf O M A, et al. Formation of hydrogen peroxide and hydroxyl radicals from Aβ and α-synuclein as a possible mechanism of cell death in Alzheimer’s disease and Parkinson’s disease[J]. Free Radical Biology and Medicine, 2002, 32(11): 1076-1083.
α-Synuclein (61-95) (human)是人源α-突触核蛋白（α-Synuclein）的核心疏水区片段，包含第61至95位氨基酸序列（NAC区域，Non-Amyloid-β Component），最初是从阿尔茨海默病（AD）淀粉样斑块的不溶性核心中分离出来的[1, 2]。α-Synuclein (61-95) (human)能够诱导神经元细胞死亡，可用于神经退行性疾病的研究，包括阿尔茨海默病（AD）和帕金森病（PD）[3, 4]。