GlpBio

Fmoc-3VVD-OH

目录号: GC60848纯度: >98%
COASDSData Sheet
Fmoc-3VVD-OH是一种可降解(non-cleavable)的ADC连接桥，用于抗体药物结合物(ADCs)的合成。
Fmoc-3VVD-OH
Cas No.: 863971-44-2
规格价格库存数量操作
10mg¥207.00现货
1
25mg¥409.00现货
1
50mg¥288.00现货
1
100mg¥414.00现货
1
10mM (in 1mL DMSO)¥228.00现货
1
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文献被引

本产品暂无引用记录;以下为 GlpBio 产品在 Nature / Cell / Science 等顶刊的客户引用样例
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    641, 529–536 (2025)
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    628, 630–638 (2024)
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    618, 1017–1023 (2023)
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    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
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    Cell
    183(7):1867-1883 (2020)
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    Science
    388(6745) (2025)
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    387(6739) (2025)
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    33, 546–561 (2023)
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    33, 904–922 (2023)
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    Cell Research
    31, 1291–1307 (2021)

产品描述 Description

Fmoc-3VVD-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

[1]. Michinori Akaiwa, et al. Synthesis and Evaluation of Linear and Macrocyclic Dolastatin 10 Analogues Containing Pyrrolidine Ring Modifications. ACS Omega. 2018 May 31;3(5):5212-5221.

产品文档 Product Documents

Purity:>98%
COASDSData Sheet

化学性质Chemical Properties

CAS 号
863971-44-2
SMILES
CN([C@H]([C@H](OC)CC(O)=O)[C@@H](C)CC)C([C@H](C(C)C)NC([C@H](C(C)C)N(C(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O)C)=O)=O
分子式
C36H51N3O7
分子量
637.81 g/mol
溶解性
DMSO: ≥ 37 mg/mL (58.01 mM); Water: < 0.1 mg/mL (insoluble)
保存条件
4°C, stored under nitroge
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol