Dodecylphosphocholine-d38 is the deuterium-labeled form of dodecylphosphocholine, in which 38 hydrogen atoms are replaced by deuterium (²H)[1]. Dodecylphosphocholine-d38 is intended for use as an internal standard for the quantification of dodecylphosphocholine by GC- or LC-MS[2]. Dodecylphosphocholine-d38 is commonly used in nuclear magnetic resonance (NMR) studies of membrane protein structures[3].
References:
[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
[2] Kurauskas, V., Hessel, A., Ma, P., et al.How detergent impacts membrane proteins: Atomic-level views of mitochondrial carriers in dodecylphosphocholineJ. Phys. Chem. Lett.9(5)933-938(2018).
[3] Hwang PM, Choy WY, Lo EI, et al. Solution structure and dynamics of the outer membrane enzyme PagP by NMR. Proc Natl Acad Sci U S A. 2002;99(21):13560-13565.
Dodecylphosphocholine-d38是十二烷基磷酸胆碱的氘标记形式，其中38个氢原子被氘（²H）取代[1]。Dodecylphosphocholine-d38能作为通过GC-或LC-MS定量十二烷基磷酸胆碱时的内标[2]。Dodecylphosphocholine-d38常用于核磁共振（NMR）研究膜蛋白结构[3]。