Flavokawain 1i

Flavokawain 1i is a derivative of the chalcones flavokawain A , flavokawain B , and flavokawain C and has anticancer and antiviral activities.^1,2 It inhibits the proliferation of gefitinib-resistant H1975 non-small cell lung cancer (NSCLC) cells by 36%, as well as decreases protein levels of the heat shock protein 90 (Hsp90) client proteins EGFR, c-Met, HER2, Akt, and cyclin-dependent kinase 4 (Cdk4) and increases protein levels of Hsp70, markers of Hsp90 inhibition, when used at a concentration of 30 µM.¹ Intramuscular administration of flavokawain 1i reduces viral titers in pigs infected with porcine reproductive and respiratory syndrome virus (PRRSV).²