Ferroptosis-IN-6 (compound 13) is a potent inhibitor of Ferroptosis with EC50 of 25.5 nM. Ferroptosis-IN-6 significantly inhibits RSL3-induced cell death in cells and in vivo.
References:
[1]. Sheng XH, et al. Design, synthesis, and biological evaluation of 2-amino-6-metl-phenol derivatives targeting lipid peroxidation with potent anti-ferroptotic activities. Eur J Med Chem. 2023 Nov 28;264:115997.