GlpBio

FDI-6

目录号: GC32972纯度: >98.00%同义词: FDI-6, Forkhead Domain Inhibitory Compound 6, NCGC00099374
An inhibitor of FOXM1 DNA-binding activity
FDI-6
Cas No.: 313380-27-7
规格价格库存数量操作
1mg¥302.00现货
1
5mg¥665.00现货
1
10mg¥1,050.00现货
1
25mg¥1,820.00现货
1
50mg¥2,800.00现货
1
100mg¥4,060.00现货
1
10mM (in 1mL DMSO)¥735.00现货
1
电话: 400-920-5774Email: sales@glpbio.cn

文献被引

本产品暂无引用记录;以下为 GlpBio 产品在 Nature / Cell / Science 等顶刊的客户引用样例
  • Nature cover
    Nature
    641, 529–536 (2025)
  • Nature cover
    Nature
    628, 630–638 (2024)
  • Nature cover
    Nature
    632, 686–694 (2024)
  • Nature cover
    Nature
    618, 1017–1023 (2023)
  • Nature cover
    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
  • Science cover
    Science
    388(6745) (2025)
  • Science cover
    Science
    387(6739) (2025)
  • Science cover
    Science
    387(6734) (2025)
  • Cell Research cover
    Cell Research
    35, 97–116 (2025)
  • Cell Research cover
    Cell Research
    34, 683–706 (2024)
  • Cell Research cover
    Cell Research
    33, 273–287 (2023)
  • Cell Research cover
    Cell Research
    33, 546–561 (2023)
  • Cell Research cover
    Cell Research
    33, 904–922 (2023)
  • Cell Research cover
    Cell Research
    31, 1291–1307 (2021)

产品描述 Description

FOXM1 inhibitor III is an inhibitor of the DNA-binding activity of forkhead box protein M1 (FOXM1; IC50 = 22.5 ?M).1 It binds to FOXM1 and is selective for inhibiting FOXM1 transcriptional activity over FOXA1, FOXA2, FOXP2, and GATA-binding factor 1 (GATA-1) transcriptional activity. FOXM1 inhibitor III inhibits the growth of MCF-7 and MDA-MB-231 breast and PEO1 ovarian cancer cells (GI50s = 18, 21.8, and 18.1 ?M, respectively).

1.Gormally, M.V., Dexheimer, T.S., Marsico, G., et al.Suppression of the FOXM1 transcriptional programme via novel small molecule inhibitionNat. Commun.55165(2014)

产品文档 Product Documents

Purity:>98.00%Appearance:A solid

化学性质Chemical Properties

CAS 号
313380-27-7
同义词
FDI-6, Forkhead Domain Inhibitory Compound 6, NCGC00099374
SMILES
O=C(C1=C(N)C2=C(C(F)(F)F)C=C(C3=CC=CS3)N=C2S1)NC4=CC=C(F)C=C4
分子式
C19H11F4N3OS2
分子量
437.43 g/mol
溶解性
DMSO : ≥ 50 mg/mL (114.30 mM)
保存条件
Store at -20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol