FAK-IN-7 (compound 5r) is a FAK inhibitor (IC50=11.72 µM). FAK-IN-7 has good anti-proliferative activity and can be used in cancer research[1].
FAK-IN-7 (0-10 µM; 48 h) inhibits MCF-7 and B16-F10 cells proliferation[1].
Cell Proliferation Assay[1]
| Cell Line: | MCF-7 and B16-F10 cells |
| Concentration: | 0-10 µM |
| Incubation Time: | 48 h |
| Result: | Exhibited anti-proliferative activity against MCF-7 and B16-F10 cells with IC50 values of 3.57 and 3.52 µM, respectively. |
[1]. Yang XH, et al. Synthesis, biological evaluation, and molecular docking studies of 1,3,4-thiadiazol-2-amide derivatives as novel anticancer agents. Bioorg Med Chem. 2012 May 1;20(9):2789-95.