Etlmalonic acid-d5 is the deuterium labeled Etlmalonic acid. Etlmalonic acid is non-carcinogenic potentially toxic and associated with anorexia nervosa and malonyl-CoA decarboxylase deficiency.
Stable heavy isotopes of drogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
[2]. Gregersen N, et al. General (medium-chain) acyl-CoA dedrogenase deficiency (non-ketotic dicarboxylic aciduria): quantitative urinary excretion pattern of 23 biologically significant organic acids in three cases. Clin Chim Acta. 1983 Aug 15;132(2):181-91
[3]. Yano S, et al. A new case of malonyl coenzyme A decarboxylase deficiency presenting with cardiomyopat. Eur J Pediatr. 1997 May;156(5):382-3.