ent-8-iso Prostaglandin F2α-d9

ent-8-iso-Prostaglandin F_2α-d₉ (ent-8-iso-PGF_2α-d₉) contains nine deuterium atoms at the 17, 17', 18, 18', 19, 19',20,20, and positions. It is intended for use as an internal standard for the quantification of ent-8-iso-PGF_2α by GC- or LC-mass spectrometry. Isoprostanes are produced by the non-enzymatic, free-radical peroxidation of arachidonic acid. They have been used as biomarkers of oxidative stress, but they also have been found to have a potent biological activity. ent-8-iso Prostaglandin F_2α (ent-8-iso PGF_2α) is a potent vasoconstrictor of porcine retinal and brain microvessels with EC₅₀ values of 31 and 54 nM, respectively.¹

1.Hou, X., Robers, L.J., II, Gobeil, F., Jr., et al.Isomer-specific contractile effects of a series of synthetic F2-isoprostanes on retinal and cerebral microvasculatureFree Radical Biology & Medicine36(2)163-172(2004)