Emoxypine succinate is an antioxidant. Emoxypine succinate can be used for the research of post-traumatic[1].
Emoxypine succinate shows reactive oxygen species overproduction and disruption of the mitochondrial inner membrane due to the decreasing of transmembrane potential[1].
Emoxypine succinate (i.p.; 40 mg/kg; 1 time per day, 14 days) decreases the production of reactive oxygen species, mitochondrial transmembrane potential percentage of leukocyte and the percentage of FITC Annexin V- positive cells of leukocyte suspension[1].
| Animal Model: | Rats[1] |
| Dosage: | 40 mg/kg |
| Administration: | Intraperitoneal, 1 time per day, 14 days |
| Result: | Significantly increased the percentage of Annexin V-positive cells, reduced the apoptotic percentage of white blood cells and decreased the production of reactive oxygen species by leukocytes. |
[1]. Krynytska, et al. Features of leukocytes' apoptosis and emoxypine succinate efficacy in case of combined trauma of the chest and both thighs in rats. Bangladesh Journal of Medical Science, (2019). 18(2), 244-251.