Eledoisin is an undecapeptide tachykinin neuropeptide and neurokinin (NK) receptor agonist originally isolated from E. moschata.1,2 It binds to NK1 (pD2 = 9.5 and 9.21 in isolated dog carotid artery and guinea pig ileum, respectively), NK2 (pD2 = 8.22 and 7.7 in isolated rabbit pulmonary artery and rat duodenum, respectively), and NK3 receptors (pD2 = 7.11 and 7.06 in isolated rat portal vein and hamster urinary bladder, respectively).3 Eledoisin induces contraction of isolated guinea pig ileum and rabbit jejunum.4 It also induces salivation in rats and lowers arterial blood pressure in rabbits and guinea pigs in vivo.4,5
1.Severini, C., Improta, G., Falconieri-Erspamer, G., et al.The tachykinin peptide familyPharmacol. Rev.54(2)285-322(2002) 2.Erspamer, V., and Anastasi, A.Structure and pharmacological actions of eledoisin, the active endecapeptide of the posterior salivary glands of EledoneExperientia18(2)58-59(1962) 3.Regoli, D., Drapeau, G., Dion, S., et al.Receptors for substance P and related neurokininsPharmacology38(1)1-15(1989) 4.Holzer-Petsche, U., Schimek, E., Amann, R., et al.In vivo and in vitro actions of mammalian tachykininsNaunyn Schmiedebergs Arch. Pharmacol.330(2)130-135(1985) 5.Hancock, J.C., and Hoover, D.B.Effect of substance P and other tachykinins on arterial pressure in guinea-pigsJ. Auton. Pharmacol.5(1)25-30(1985)