EF24 is a novel synthetic curcumin analog [1]. EF24 induces apoptosis of cancer cells through a redox-dependent mechanism [2]. EF24 has anti-tumor and anti-aging effects [3-4].
In A549 cells, EF24 (0μM, 0.5μM, 1μM, 2μM, 4μM, 8μM, 16μM; 24h, 48h) inhibits the growth of NSCLC cells in vitro [5]. In K562 cells, EF24 (2μM; 24h) exhibits potent cell killing activity in leukemia cell lines [6]. In SKOV-3, EF24 (3μM; 48h) treatment attenuates ovarian cancer cell proliferation and metastasis [7].
In subcutaneous HCC tumor mice model, EF24 (20mg/kg; ip; 21d) inhibits tumor growth and induces apoptosis [8]. In C57/BL6 mice, EF24 (200μg/kg; ip; 14d) significantly inhibited the significant increase in JunB, JunC, and JunD levels in distant lung tissues after infrared irradiation [9]. In DU145 subcutaneous tumor mice model, EF24 (200μg/kg; ip; 4 weeks) treatment significantly slowed tumor growth [10].
References:
[1]. He Y, Li W, Hu G, et al. Bioactivities of EF24, a novel curcumin analog: a review. Frontiers in Oncology. 2018 Dec 11; 8: 614.
[2]. Adams BK, Cai J, Armstrong J, et al. EF24, a novel synthetic curcumin analog, induces apoptosis in cancer cells via a redox-dependent mechanism. Anti-cancer drugs. 2005 Mar 1;16(3):263-275.
[3]. Sazdova I, Keremidarska-Markova M, Dimitrova D, et al. Anticarcinogenic potency of EF24: An overview of its pharmacokinetics, efficacy, mechanism of action, and nanoformulation for drug delivery. Cancers. 2023 Nov 20; 15(22): 5478.
[4]. Li W, He Y, Zhang R, et al. The curcumin analog EF24 is a novel senolytic agent. Aging (Albany NY). 2019 Jan 28;11(2):771.
[5]. Chang M, Shang M, Yuan F, et al. EF24 exerts cytotoxicity against NSCLC via inducing ROS accumulation. Cancer Cell International. 2021 Dec; 21: 1-3.
[6]. Singh AP, Wax N, Duncan J, et al. Genomic Discovery of EF-24 Targets Unveils Antitumorigenic Mechanisms in Leukemia Cells. bioRxiv. 2024 Oct 16: 2024-2010.
[7]. Zhang D, Wang Y, Dong L, et al. Therapeutic role of EF 24 targeting glucose transporter 1‐mediated metabolism and metastasis in ovarian cancer cells. Cancer science. 2013 Dec; 104(12): 1690-1696.
[8]. Liu H, Liang Y, Wang L, et al. In vivo and in vitro suppression of hepatocellular carcinoma by EF24, a curcumin analog. PloS one. 2012 Oct 31; 7(10): e48075.
[9]. Veeraraghavan J, Natarajan M, Awasthi V, et al. EF24, a novel curcumin analogue inhibits oncogenic activation induced by radiation abscopal effect in distant mice lungs. Cancer Research. 2011 Apr 15;71(8_Supplement):4203.
[10]. Yang CH, Yue J, Sims M, et al. The curcumin analog EF24 targets NF-κB and miRNA-21, and has potent anticancer activity in vitro and in vivo. PloS one. 2013 Aug 7; 8(8): e71130.
EF24是一种新型合成姜黄素类似物 [1]。EF24通过氧化还原依赖机制诱导癌细胞凋亡 [2]。EF24具有抗肿瘤和抗衰老作用 [3-4]。
在A549细胞中，EF24（0μM、0.5μM、1μM、2μM、4μM、8μM、16μM；24h、48h）可抑制体外非小细胞肺癌（NSCLC）细胞的生长 [5]。在K562细胞中，EF24（2μM；24h）对白血病细胞系表现出强大的细胞杀伤活性 [6]。在SKOV-3细胞中，EF24（3μM；48h）治疗可减弱卵巢癌细胞的增殖和转移 [7]。
在皮下HCC肿瘤小鼠模型中，EF24（20mg/kg；ip；21d）可抑制肿瘤生长并诱导细胞凋亡 [8]。在C57/BL6小鼠中，EF24（200μg/kg；ip；14d）显著抑制了红外照射后远处肺组织中JunB、JunC和JunD水平的显著升高 [9]。在DU145皮下肿瘤小鼠模型中，EF24（200μg/kg；ip；4周）治疗显著减缓了肿瘤生长 [10]。