Ecamsule disodium is a water-soluble broad-spectrum long-wave ultraviolet light (UVA)-absorber covering a wide range of UVA radiation from 300 to 400nm, with maximum absorbance at 344nm. Ecamsule disodium exhibited significant protection against UV induced and chemical oxidative stress (AAPH)-induced ROS levels[1][2]. Ecamsule disodium provides clinical benefit to patients with polymorphous light eruption (PMLE)[3].
In vitro, Ecamsule disodium (200-1600μM) was applied to human keratinocyte (HaCaT) and fibroblast (WT Fibs E6/E7) cell lines for 1h before exposure to UV radiation. Ecamsule disodium significantly reduced UV-induced ROS levels in fibroblasts and keratinocytes by up to 25.7% and 14.5% respectively at 1600μM[1]. Ecamsule disodium (50, 500, and 5000ng/L) was applied on digestive glands and gills tissues of Mytilus galloprovincialis mussle for 30min. Ecamsule disodium has a relatively low toxicological impact comparing to other UV filters such as Ethylhexylmethoxycinnamate (EHMC) and Octocrylene (OC). Ecamsule disodium did not induce oxidative stress or cellular damage and only slightly enhanced biotransformation enzyme activity (CbEs) in digestive glands[2].
References:
[1] Hofer S, Stonig M, Wally V, et al. Contradictory effects of chemical filters in UV/ROS-stressed human keratinocyte and fibroblast cells. ALTEX. 2019;36(2):231-244.
[2] Bordalo D, Soares A M V M, Sokolova I, Pretti C, Freitas R. Hidden costs of beauty: An in vitro study on the ecotoxicological impacts of ultraviolet filters and parabens on the bioindicator species Mytilus galloprovincialis. Mar Pollut Bull. 2025 Nov:220:118403.
[3] DeLeo V A, Clark S, Fowler J, et al. A new ecamsule-containing SPF 40 sunscreen cream for the prevention of polymorphous light eruption: a double-blind, randomized, controlled study in maximized outdoor conditions. Cutis. 2009 Feb;83(2):95-103.
Ecamsule disodium是一种水溶性的广谱长波紫外线（UVA）吸收剂，覆盖300–400nm的UVA波段，最大吸收峰位于344nm。Ecamsule disodium在UV诱导及化学氧化应激（AAPH）条件下均显著抑制ROS生成[1][2]，并对多形性日光疹（PMLE）患者具有临床益处[3]。
体外实验中，Ecamsule disodium（200–1600μM）提前作用于人角质形成细胞（HaCaT）和成纤维细胞（WT Fibs E6/E7）1h，再接受UV刺激，在1600μM时，Ecamsule disodium分别使成纤维细胞和角质细胞的UV诱导ROS水平降低25.7%和14.5%[1]。Ecamsule disodium（50、500、5000ng/L）处理Mytilus galloprovincialis贻贝消化腺和鳃组织30min，与Ethylhexylmethoxycinnamate（EHMC）和Octocrylene（OC）等UV滤光剂相比，Ecamsule disodium毒性较低，未引起氧化应激或细胞损伤，并且仅在消化腺中轻微增强了生物转化酶活性（CbEs）[2]。