E3 ligase Ligand 5

PROTAC ERRα ligand 1 is an estrogen-related receptor α (ERRα) antagonist with IC₅₀s of 0.04 and 2.8 μM for ERRα and ERRγ, respectively^[1].

References:

[1]. Patch RJ, et al. Identification of diaryl ether-based ligands for estrogen-related receptor α as potential antidiabetic agents. J Med Chem. 2011 Feb 10;54(3):788-808.

PROTAC ERRa ligand 1是雌激素相关受体a(ERRa)拮抗剂，对ERRa和 ERRy的IC₅₀ 分别为0.04和 2.8μM。