DSPE-PEG(2000)-amine is the amine derivative of phospholipid poly ethylene glycol with biocompatible and biodegradable properties [1]. DSPE-PEG(2000)-amine can be used to encapsulate liposomes and facilitate the passage of liposomes through the blood-brain barrier[2]. DSPE-PEG(2000)-amine can self-assemble into micelles and are easily modified, which participates in lipid transfer to design targeted liposomes, thereby protecting the targeting ligands during circulation[3]. DSPE-PEG(2000)-amine has been widely used in the preparation of liposomes and polymer nanoparticles to reduce the in vivo clearance rate and plasma protein adsorption of cholesterol-free lipid formulations, prolong the in vivo circulation time, increase targeting ability and improve bioavailability[4].
References:
[1] Sun F, Jaspers T C C, van Hasselt P M, et al. A Mixed Micelle Formulation for Oral Delivery of Vitamin K: Sun et al[J]. Pharmaceutical research, 2016, 33(9): 2168-2179.
[2] Vijayakumar M R, Kosuru R, Vuddanda P R, et al. Trans resveratrol loaded DSPE PEG 2000 coated liposomes: an evidence for prolonged systemic circulation and passive brain targeting[J]. Journal of drug delivery science and technology, 2016, 33: 125-135.
[3] Li W M, Xue L, Mayer L D, et al. Intermembrane transfer of polyethylene glycol-modified phosphatidylethanolamine as a means to reveal surface-associated binding ligands on liposomes[J]. Biochimica et Biophysica Acta (BBA)-Biomembranes, 2001, 1513(2): 193-206.
[4] Wang R, Xiao R, Zeng Z, et al. Application of poly (ethylene glycol)–distearoylphosphatidylethanolamine (PEG-DSPE) block copolymers and their derivatives as nanomaterials in drug delivery[J]. International journal of nanomedicine, 2012: 4185-4198.
DSPE-PEG(2000)-amine是一种具有生物相容性和可生物降解性的磷脂-聚乙二醇胺衍生物[2]。DSPE-PEG(2000)-amine可用于包封脂质体，并促进脂质体通过血脑屏障[2]。DSPE-PEG(2000)-amine可自组装形成胶束，且易于修饰，参与脂质转移以设计靶向脂质体，从而在循环过程中保护靶向配体[3]。DSPE-PEG(2000)-amine已被广泛用于制备脂质体和聚合物纳米颗粒，以降低无胆固醇脂质制剂的体内清除率和血浆蛋白吸附，延长体内循环时间，增加靶向能力并提高生物利用度[4]。