GlpBio

DMX-5804

目录号: GC65298纯度: >99.00%
DMX-5804 is a potent, orally active and selective inhibitor of Mitogen-activated protein kinase kinase kinase kinase-4 (MAP4K4) with IC50 of 3 nM for human MAP4K4. DMX-5804 is more potent on human MAP4K4 with pIC50 of 8.55 than MINK1/MAP4K6 and TNIK/MAP4K7 with pIC50 of 8.18 and 7.96, respectively.
DMX-5804
Cas No.: 2306178-56-1
规格价格库存数量操作
5mg¥2,700.00现货
1
10mg¥4,320.00现货
1
10mM (in 1mL DMSO)¥2,970.00现货
1
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文献被引

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    641, 529–536 (2025)
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产品描述 Description

DMX-5804 is a potent, orally active and selective inhibitor of Mitogen-activated protein kinase kinase kinase kinase-4 (MAP4K4) with IC50 of 3 nM for human MAP4K4. DMX-5804 is more potent on human MAP4K4 with pIC50 of 8.55 than MINK1/MAP4K6 and TNIK/MAP4K7 with pIC50 of 8.18 and 7.96, respectively.

[1] Lorna R Fiedler, et al. Cell Stem Cell. 2019 Apr 4;24(4):579-591.e12.

实验参考方法 Experimental Reference Method

MAP4K4

3nM(IC50)

MAP4K4

8.55(pIC50)

MINK1/MAP4K6

8.18(pIC50)

TNIK/MAP4K7

7.96(pIC50)

GCK/MAP4K2

6.50(pIC50)

KHS/MAP4K5

6.36(pIC50)

GLK/MAP4K3

4.95(pIC50)

MLK1/MAP3K9

7.19(pIC50)

MLK3/MAP3K11

6.99(pIC50)

NUAK

6.88(pIC50)

VEGFR

5.72(pIC50)

ABL1

5.80(pIC50)

AuroraB

5.49(pIC50)

FLT3

5.31(pIC50)

GSK3β

4.66(pIC50)

产品文档 Product Documents

Purity:>99.00%

化学性质Chemical Properties

CAS 号
2306178-56-1
分子式
C21H19N3O3
分子量
361.39 g/mol
溶解性
DMSO : 125 mg/mL (345.89 mM; Need ultrasonic)
保存条件
Store at -20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol