Diniconazole is a broad-spectrum triazole fungicide that inhibits ergosterol biosynthesis via inhibition of the cytochrome P450-dependent 14α-demethylation of lanosterol, which results in disruption of the fungal cell membrane and cell death.1 It is fungicidal against B. cinerea, S. fimicola, F. graminearum, S. cepivorum, and B. sorokiniana (EC50s = 0.012, <0.001, 0.008, 0.02, and 0.06 mg/l, respectively).2 Diniconazole acts as a plant growth regulator, decreasing height and leaf area in bean plants when applied to roots at a concentration of 5 mg/l. It exhibits dose-dependent toxicity in zebrafish.3
1.Yoshida, Y., Aoyama, Y., Takano, H., et al.Stereo-selective interaction of enantiomers of diniconazole, a fungicide, with purified P-450/14DM from yeastBiochem. Biophys. Res. Commun.137(1)513-519(1986) 2.Fletcher, R.A., Hofstra, G., and Gao, J.Comparative fungitoxic and plant growth regulating properties of triazole derivativesPlant Cell Physiol.27(2)367–371(1986) 3.Jing, G., Wen-hua, S., Feng, D., et al.Acute toxicity study on zebrafish (Danio rerio) exposure to triazole fungicidesJ. SE Univ. (Med. Sci. Ed.)29(4)402-406(2010)