8-iso Prostaglandin F1α-d9

8-iso Prostaglandin F_1α-d₉ (8-iso PGF_1α-d₉) contains nine deuterium atoms at the 17, 17', 18, 18', 19, 19', 20, 20, and 20 positions. It is intended for use as an internal standard for the quantification of 8-iso PGF_1α by GC- or LC-mass spectrometry. 8-iso PGF_1α is an isoprostane that was first identified in human semen.¹ It is a member of the isoprostane family, which are eicosanoids of non-cyclooxygenase origin. 8-iso PGF_1α is present along with its 19-hydroxy congener at 5-10 µg/ml of seminal plasma.²

1.Svanborg, K., Bygdeman, M., and Eneroth, P.The F and 19-hydroxy F prostaglandins and their 8β-isomers in human seminal plasma: Data on chromatography and mass spectrometryBiomedical Mass Spectrometry10495-498(1983) 2.Taylor, P.L.The 8-isoprostaglandins: Evidence for eight compounds in human semenProstaglandins17259-267(1979)