Dihydrostreptomycin is an aminoglycoside antibiotic and a derivative of streptomycin .1 It is active against B. subtilis, K. pneumoniae, S. marcescens, S. aureus, P. aeruginosa, and M. tuberculosis (MICs = 0.07, 0.08, 0.09, 0.06, 0.8, and 5.7 ?g/ml, respectively). It interferes with bacterial protein synthesis by binding the 30S ribosomal subunit.2 Dihydrostreptomycin enhances phagocytosis and intracellular killing of E. coli by isolated mouse peritoneal macrophages.3 It improves survival in a mouse model of S. aureus infection.4 Formulations containing dihydrostreptomycin have been used in the prevention and treatment of bacterial infections in livestock.
1.Donovick, R., and Rake, G.Studies on some biological aspects of dihydrostreptomycinJ. Bacteriol.53(2)205-211(1947) 2.Kaji, H., and Tanaka, Y.Binding of dihydrostreptomycin to ribosomal subunitsJ. Mol. Biol.32(2)221-230(1968) 3.Adam, D., Staber, F., Belohradsky, B.H., et al.Effect of dihydrostreptomycin on phagocytosis of mouse-peritoneal macrophages in vitroInfect. Immun.5(4)537-541(1972) 4.Waksman, S.A., Frankel, J., and Graessle, O.The in vivo activity of neomycinJ. Bacteriol.58(2)229-237(1949)