Dicloxacillin is a semisynthetic penicillin antibiotic that has activity against Gram-positive bacteria (MICs = 0.02-0.24 μg/ml for S. pyogenes, S. aureus, and D. pneumoniae).1 Dicloxacillin is protective against S. pyogenes, S. aureus, and D. pneumoniae infections in mice when administered subcutaneously or orally (PD50s = 12-185 and 41-280 mg/kg, respectively). Formulations containing dicloxacillin have been used prophylactically during catheterization and in dog bite patients.
1.Miraglia, G.J., and Basch, H.I.Activity of selected penicillins in vitro and in experimental bacterial infections in miceAppl. Microbiol.15(3)566-568(1967)