Deltasonamide 1 is a PDE6δ-KRas inhibitor. Deltasonamide 1 can inhibit PDE6δ-KRas with a KD of 203 pM. Deltasonamide 1 can be used for the research of tumors[1].
Deltasonamide 1 可以抑制 PDE6δ-KRas，KD 为 203 pM[1]。
Deltasonamide 1 通过多达 7 个氢键与 PDE6δ 结合，产生皮摩尔亲和力[1]。
Deltasonamide 1 强烈减少增殖[1]。
Cell Proliferation Assay[1]
| Cell Line: | RTCA of hPDAC cell lines. |
| Concentration: | 0.375, 0.75, 1.5, 3, 6, 12 μM. |
| Incubation Time: | 60 h. |
| Result: | Inhibited proliferation of human pancreatic cancer cell lines. |
[1]. Pablo MartÍn-Gago, et al. A PDE6δ-KRas Inhibitor Chemotype With Up to Seven H-Bonds and Picomolar Affinity That Prevents Efficient Inhibitor Release by Arl2. Angew Chem Int Ed Engl. 2017 Feb 20;56(9):2423-2428.