GlpBio

Debio 0123 (hydrochloride)

目录号: GC92030纯度: >98.00%同义词: WEE1-IN-5; WEE1 Inhibitor 5
Debio 0123 (hydrochloride)是检查点激酶WEE1的抑制剂，IC50 = 0.8 nM。
Debio 0123 (hydrochloride)
规格价格库存数量操作
1 mg¥784.00现货
1
5 mg¥3,528.00现货
1
10 mg¥6,272.00现货
1
25 mg¥12,740.00现货
1
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文献被引

本产品暂无引用记录;以下为 GlpBio 产品在 Nature / Cell / Science 等顶刊的客户引用样例
  • Nature cover
    Nature
    641, 529–536 (2025)
  • Nature cover
    Nature
    628, 630–638 (2024)
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    Nature
    632, 686–694 (2024)
  • Nature cover
    Nature
    618, 1017–1023 (2023)
  • Nature cover
    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
  • Science cover
    Science
    388(6745) (2025)
  • Science cover
    Science
    387(6739) (2025)
  • Science cover
    Science
    387(6734) (2025)
  • Cell Research cover
    Cell Research
    35, 97–116 (2025)
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    Cell Research
    34, 683–706 (2024)
  • Cell Research cover
    Cell Research
    33, 273–287 (2023)
  • Cell Research cover
    Cell Research
    33, 546–561 (2023)
  • Cell Research cover
    Cell Research
    33, 904–922 (2023)
  • Cell Research cover
    Cell Research
    31, 1291–1307 (2021)

产品描述 Description

Debio 0123 is an inhibitor of the checkpoint kinase WEE1 (IC50 = 0.8 nM).1 In vivo, debio 0123 (30 mg/kg per day), in combination with the inhibitor of topoisomerase II etoposide , reduces tumor volume in a patient-derived xenograft (PDX) mouse model of stomach cancer.2

References:
[1]. Hewitt, P., Burkamp, F., Wilkinson, A., et al.Pyrimidopyrimidones usefulL as WEE-1 kinase inhibitors(2018).
[2]. Rodrigo Imedio, E., Piggott, L., Bellon, A., et al.Methods OF treating small cell lung cancer(2023).

产品文档 Product Documents

Purity:>98.00%

化学性质Chemical Properties

同义词
WEE1-IN-5; WEE1 Inhibitor 5
化学名
3-(2,6-dichlorophenyl)-2,3-dihydro-1-methyl-7-[[3-methyl-4-(1-methyl-4-piperidinyl)phenyl]amino]-pyrimido[4,5-d]pyrimidin-4(1H)-one, hydrochloride
SMILES
O=C1C2=CN=C(NC3=CC=C(C4CCN(CC4)C)C(C)=C3)N=C2N(CN1C5=C(Cl)C=CC=C5Cl)C.Cl
分子式
C26H28Cl2N6O ? XHCl
分子量
511.4 g/mol
溶解性
Methanol: Soluble
保存条件
-20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol