DC-BPi-11 drochloride is an inhibitor of bromodomain PHD finger transcription factor (BPTF), with an IC50 value of 698 nM. DC-BPi-11 drochloride shows remarkable inhibition against leukemia cell proliferation[1].
DC-BPi-11 drochloride (0.1 nM-1 μM; 24 h) 抑制人白血病MV-4-11细胞中的BPTF, EC50 为 120 nM[1]。
DC-BPi-11 drochloride (0.01 μM-100 μM; 24 h) 显著抑制人白血病 MV-4-11 细胞增殖 (IC50=0.89 μM)，而且 (2.5 ~ 20 μM; 24 h) 还降低下游癌基因表达[1]。
DC-BPi-11 drochloride (0.6-50 μM; 24 h) 剂量依赖性地降低 c-Myc 蛋白水平[1]。
DC-BPi-11 drochloride 是安全的，对正常细胞的影响小[1]。
[1]. Lu T, et al. Discovery of High-Affinity Inhibitors of the BPTF Bromodomain. J Med Chem. 2021 Aug 26;64(16):12075-12088.